Fig. 4: Refined prognostic subtypes derived from 1,063 CRC transcriptomes.
From: Prognostic genome and transcriptome signatures in colorectal cancers
The characteristics of the five distinct CRPSs obtained from unsupervised classification of tumour transcriptome data. a, Comparison of CRPS to the CMSs for the same dataset. The proportion of samples assigned to each subtype is shown as the percentage of the total number of tumours. The main molecular and clinical characteristics for each CRPS and CMS subgroup are indicated. b, Transcriptomic characteristics of 1,063 samples according to their CRPS classification. Prognostic focal CNV cytobands that are differentially altered in CRPS are indicated by asterisks (P < 0.05, multivariable Cox regression in nHM tumours). c, Kaplan–Meier survival curves (log-rank test) for overall (stages I–IV) and recurrence-free (stages I–III) survival in CRPS (top) and CMS (bottom) groups. d, Kaplan–Meier survival curves (log-rank test) for CMS4 samples allocated to CRPS2 and CMS4 samples allocated to the CRPS4 group. Adjusted HR (HRadj) and P values (Padj) or HR and P values were calculated using multivariable Cox regression with or without adjustment for tumour stage. CIN, chromosomal instability.
