Extended Data Fig. 3: Identification of novel and prognostic somatic mutational signatures.
From: Prognostic genome and transcriptome signatures in colorectal cancers
De novo signature extraction and Cosmic signature decomposition by SigProfilerExtraction. Signatures of (a) single-base substitution, (b) doublet-base substitution, (c) and small insertion and deletion sorted by median (red line) mutational burden per megabase with each dot representing one tumour and the number of tumours with each signature indicated below. d, Overall survival of patients with stage I-IV hypermutated tumours (n = 242) having the DNA mismatch repair SBS44 signature with Kaplan-Meier curves and log-rank test. e, SigProfilerExtraction profiles for the novel and SBS-CRC2, doublet-base substitution DBS-CRC1, DBS-CRC2, DBS-CRC3, DBS-CRC4 and DBS-CRC5 and small insertion and deletion ID-CRC1 and ID-CRC2 signatures. SBS, single-base substitution; DBS, doublet-base substitution; ID, small insertions and deletions; MMR, mismatch repair; MSS, microsatellite stable.
