Table 1 Prognostic genomic features by hypermutation status
From: Prognostic genome and transcriptome signatures in colorectal cancers
Feature | nHM | HM | ||
|---|---|---|---|---|
Longer survival | Shorter survival | Longer survival | Shorter survival | |
Coding driver gene mutation | APCOS,RFS SIN3AOS | ARHGAP5OS,RFS ARID2OS BRAF OS,RFS RNF43OS,RFS | ARHGAP5RFS RNF43RFS TGFBR2RFS | BCL9OS PCBP1RFS TRPS1OS |
Mitochondrial gene mutation | MT-CYBOS,RFS | − | − | − |
Non-coding driver gene mutation | − | ID2OS HS3ST1OS DAPK1RFS | − | − |
CNV | +8p11.1OS +20q11.1OS,RFS +20q11.21OS +20q13.12OS +20q13.33OS | −4q34.1OS −8p23.1OS −11p15.5RFS −12q24.33RFS −16p13.3RFS −17p12RFS −17p13.3RFS −17q12OS −17q21.2OS −17q21.31OS −17q25.3OS,RFS −21p12OS | − | −3p21.31RFS −4q22.1RFS −11p15.5OS,RFS −15q26.3RFS +19q11OS |
SV | − | SMAD4RFS TCF7L2OS,RFS | − | − |
Mutational signature | − | − | SBS44OS | − |
