Fig. 4: PC activity can be stable despite environmental changes when path integration is uninterrupted.
From: A population code for spatial representation in the zebrafish telencephalon
a, Schematic of the light/dark experiment (Methods). b, Change in distribution of telencephalic PCs with confined PFs (Methods). PCs defined in S1 or S2 are plotted separately (left and right, respectively) for an example animal. Each dot represents the COM of one cell’s PF, colour coded by its position in the chamber (top, S1; bottom, S2). c, Example spatial activity maps (one cell per column). d, Spatial activity map correlation (PF cor.), population vector correlation (PV cor.) and shift in PF location (PF shift; Methods) are shown from left to right. Comparisons between S1 and S2 (red) are plotted together with control comparisons between the early (first half) and late (second half) periods of S1 (black). Solid lines denote mean distributions across all fish, shaded regions denote s.d. across all fish and vertical dashed lines represent medians of averaged distributions (the same applies to all histograms in this figure). e, Schematic of landmark-removal experiment (Methods). f–h, Analysis of landmark-removal experiment; f,g,h correspond to b,c,d, respectively. i, Schematic of wall-morphing experiment (Methods). j–l, Analysis of wall-morphing experiment; j,k,l correspond to b,c,d, respectively. To facilitate comparisons in l, we represent the activity of both sessions in terms of the spatial bins of S1 (see Methods for non-rigid morphing of the S2 spatial activity map). m, Schematic of chamber-rotation experiment. Between sessions the entire chamber including the fish is rotated 180° relative to the microscope (Methods). n,o, Analysis of chamber-rotation experiment; n,o correspond to b,c, respectively. p, Summary of map changes in telencephalic PCs across the two sessions by direct comparison of maps in the microscope reference frame. q, Similar to l, but the comparison is made in the chamber reference frame by rotating the spatial activity maps (Methods). Statistical tests for individual animals are summarized in Extended Data Fig. 6a. Scale bars, 10 mm.
