Fig. 6: PCs exhibit representational flexibility across distinct environments.
From: A population code for spatial representation in the zebrafish telencephalon
a, Schematic of the experiment combining landmark removal, wall morphing and fish removal. Following S1, the fish was removed and transferred to a chamber with a different geometry and no landmarks for S2 (Methods). b–d, Analysis of experiment performed as in Fig. 4j–l, respectively. d, For all histograms, solid lines indicate mean distributions across all fish, shaded regions indicate s.d. across all fish and vertical dashed lines indicate medians of averaged distributions. Results of statistical tests for individual animals are summarized in Extended Data Fig. 6a. e, We quantify the degree to which neighbourhood relationships between telencephalic PCs are maintained across sessions (‘neighbour retention %’; Methods). For each PC, neighbours are defined as cells with the highest PF correlation to the cell of interest, with a systematically varied inclusion threshold from the top 2% to the top 100%. Neighbour retention % is defined as the number of PCs that remain neighbours in S2 divided by the number of original neighbours in S1. The average neighbour retention % across PCs between S1 and S2 (solid red line) is plotted against the control comparison between the early and late stages of S1 (solid black line), as well as against comparisons with shuffled data (solid grey line). We also subdivided neurons into two groups based on the distance of each place field to the edge of the chamber in S1 (dashed lines represent distance to edge 3 mm or less, 233 ± 135 cells, mean ± s.d.; dotted lines represent distance to edge greater than 3 mm, 352 ± 171 cells, mean ± s.d.). Scale bars, 10 mm.
