Extended Data Fig. 8: The absence of the GD3-IL-3-sensory neuron axis inhibits papain-induced Th2-skewing dendritic cell migration.
From: A γδ T cell–IL-3 axis controls allergic responses through sensory neurons
a, Schematic of the allergic immune response protocol. b,c,e, Flow cytometry of the draining lymph node (dLN) 24 h after immunization with ova ± papain (gating strategy corresponding to Fig. 4a, b, i, k). d,f,g, Flow cytometric quantification of the draining lymph node (dLN) 24 h after immunization with ova ± papain (d, n = 10 per group; f, n = 12 iTcrdcre/+Il3+/+; n = 11 iTcrdcre/+Il3fl/fl; n = 10 Scn10acre/+Il3ra+/+; n = 11 Scn10acre/+Il3rafl/fl; g, n = 12 iso; n = 11 keta). Symbols represent individual mice. Symbols connected by lines indicate paired samples derived from the same mouse. Data represent at least two independent experiments and were combined. Statistical tests: two-way repeated measures ANOVA (d,f,g). * p < 0.05, ** p < 0.01, **** p < 0.0001, ns=not significant. Schematic in a created using BioRender (https://biorender.com).
