Extended Data Fig. 4: GD3 cells are regulated by Trgv4, age, microbial factors, and dry skin.
From: A γδ T cell–IL-3 axis controls allergic responses through sensory neurons
a-c,e-h, Flow cytometric quantification from pinnae (a, n = 12 WT; n = 11 Trgv4-/-; b, n = 11 8–12 weeks; n = 9 8–12 months; c, n = 12 per group; e, n = 16 per group; f, n = 4 WT; n = 7 per shop; g, n = 7 sham; n = 9 AEW; h, n = 11 sham; n = 15 AEW). d, Cumulative cheek scratch bouts following i.d. injection of papain (n = 12 per group). Symbols represent individual mice. Bar plots are the mean ± SEM. Violin plots show the median and quartiles. Data represent at least two independent experiments and were combined, except in f. Statistical tests: two-sided unpaired t-test (a; b, DETCs; f, dermal γδ T cells and DETCs; g; h, DETCs) or two-sided Mann-Whitney U-test (b, dermal γδ T cells and GD3 cells; c-e; f, GD3 cells; h, dermal γδ T cells and GD3 cells). * p < 0.05, ** p < 0.01, *** p < 0.001, ns=not significant.
