Extended Data Fig. 6: Lung pathology and viral titers after SARS-CoV-2 infection.
From: Fibrin drives thromboinflammation and neuropathology in COVID-19
a, Microscopy of NK1.1 in lung after Beta-infection at 3 d.p.i. n = 5 mice per group. b, Microscopy of N protein in lung after infection at 3 d.p.i; Infected, n =5 WT, n = 5 Fga–/–, n = 4 Fggγ390-396A mice. c, Box-and-whisker plots showing the number of PFUs propagated from lung homogenates of infected animals on Vero cells. PFU/ml from lung homogenates of Beta-infected n = 10 WT, n = 10 Fga–/– and n = 9 Fggγ390–396A mice at 3 d.p.i. P values shown by Welch two-sample two-sided t-test followed by multiple correction testing using the Holm procedure. Box indicates the interquartile range (IQR) and whiskers denote the 1.5 × IQR. a, b, One-way ANOVA with Tukey’s multiple comparisons test. All data are mean ± s.e.m. Scale bars, 100 μm.
