Extended Data Fig. 4: Lung microscopy from SARS-CoV-2 infection.
From: Fibrin drives thromboinflammation and neuropathology in COVID-19
a, Microscopy of hematoxylin and eosin staining from lung of WT, Fga–/– and Fggγ390–396A mice after Beta infection or uninfected (UI) WT mice. Representative images from UI n = 4; Infected, WT n = 5, Fga–/– n = 5 and Fggγ390–396A n = 4 mice. Scale bar, 200 μm b, Microscopy of fibrin(ogen) (red), Spike (green), Mac-2 (green), and gp91-phox (red) immunoreactivity in the lung from UI mice. Nuclei are stained with DAPI (blue). Scale bar, 70 μm. Representative images from n = 3 mice per group. c, Microscopy for 4-HNE in lung from UI n = 5 and Beta-infected n = 5 WT, n = 5 Fga–/–, n = 4 Fggγ390–396A mice. One-way ANOVA with Tukey’s multiple comparisons test. All data are mean ± s.e.m. Scale bars, 100 μm.
