Extended Data Fig. 5: F18-mix decolonizes Kp-2H7 by a mechanism independent of the host’s major immune system.
From: Commensal consortia decolonize Enterobacteriaceae via ecological control
a, b, GF Ifngr1−/− (a), Myd88−/−Ticam1−/−, Rag2−/−Il2rg−/− (b), or wild-type (WT) B6 mice were monocolonized with Kp-2H7, followed by oral administration of F18-mix. Faecal Kp-2H7 CFUs were counted until day 28 post-F18-mix administration. Data are expressed as median ± IQR and compared by Mann-Whitney U test (two-sided) (a) or Kruskal-Wallis using the Benjamini-Hochberg correction for multiple comparisons (b) on samples at day 28. c, Heatmap depicts the expression of genes associated with defence response and peroxisome proliferator-activated receptor γ (PPARγ)-inducible genes in colonic epithelial cells from mice colonized with the indicated bacterial mix. Defence response genes and PPARγ-inducible genes were selected based on gene ontology term.
