Extended Data Fig. 7: Intragenic invertons that recode proteins are identified in long-read isolate datasets.
From: Intragenic DNA inversions expand bacterial coding capacity
(A-C) Genome diagrams for recoding intragenic invertons are shown. Grey boxes indicate annotated protein domains. Black lines indicate the region contained within the inverton. AlphaFold structure of the forward (dark blue) and reverse (light blue) are shown. Amino acids affected by the inverton are shown in pink. (A) slmA nucleoid occlusion factor Bordetella bronchiseptica. RMSD 26.287 angstroms across all pairs. pLDDT forward: 94.5. pLDDT reverse: 51.3. (B) barA two-component sensor histidine kinase in Aeromonas hydrophila. The Receiver and HPt domain are shown. RMSD 5.492 angstroms across all pairs. pLDDT forward: 83.4. pLDDT reverse: 76.2. (C) Type I restriction enzyme S subunit hsdS1 and hsdS2 in Mycoplasma hominis. RMSD 1.809 and 4.167 angstroms across all pairs, respectively. pLDDT hsdS1 forward 90.8, reverse 87. pLDDT hsdS2 forward 92.4, reverse 84.2. HTH, helix-turn-helix; HK, histidine kinase; HPt, histidine phosphotransfer domain; TRD, target recognition domains.
