Extended Data Fig. 11: BTSP induces EPSP potentiation and plateau potentials observed during Ca2+ imaging experiments.
From: Dendritic, delayed, stochastic CaMKII activation in behavioural time scale plasticity
a, Left: A representative dendrite of a neuron filled with Cal-590. “+” depicts the BTSP stimulated spine, Right: Average EPSP traces before and after BTSP protocol. b, Averaged time course of normalized EPSP amplitude in stimulated and adjacent spines. The gap in EPSP recording shows the time of calcium imaging (Fig. 4a–c). The arrow depicts BTSP induction. c, Group summary plot shows a higher magnitude of potentiation in stimulated spines than adjacent spines. The data are presented as mean and individual values. Two-tailed unpaired t-test (t(22) = 3.367, p = 0.003). d, Representative traces of voltage recordings showing that plateau potentials had corresponding Ca2+ traces (red *) in a majority of the examples (58/74, 3-standard deviation for Ca2+). The number of cells is mentioned in the figure panels. ***p < 0.01.
