Extended Data Fig. 8: scRNAseq analysis of muscles with or without 11,12-EET treatment.
From: Gasdermin D-mediated metabolic crosstalk promotes tissue repair
a-i, Heatmap of signature marker genes of each cell type (a, upper), and dynamics of cell type population after injury (a, lower). UMAP plot and percentage of each cell type with indicated treatment (b). Feature plot of signature marker genes of each cell type (c). UMAP plot of 6 consecutive MuSC states and changes of cell proportion upon 11,12-EET treatment (d). Dotplot of signature marker genes of each state of MuSCs (e). Trajectory analysis and the density plots of the relative number of MuSCs separately for 11,12-EET treatment or vehicle (f,g). Red arrow indicates the enriched proliferation lineage and more terminally-differentiated Myoghi MuSCs upon 11,12-EET treatment. Dotplot of the enrichment scores of the indicated gene sets (h). Correlation between FGF binding capacity and P38MAPK cascade level of MuSCs with the indicated treatment (i). Pearson correlation analysis for (i).
