Extended Data Fig. 6: The heteromeric filament fold of ANXA11 and TDP-43 from FTLD-TDP Type C.
From: Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C
a, Secondary structure of the heteromeric filament fold of FTLD-TDP Type C, shown for single ANXA11 and TDP-43 molecules perpendicular to the helical axis. b, Atomic model of the filament fold depicting hydrogen bonding (dashed cyan lines), shown for three ANXA11 and TDP-43 molecules perpendicular to the helical axis. c, Hydrophobicity of the filament fold, from most hydrophilic (teal) to most hydrophobic (yellow), shown for single ANXA11 and TDP-43 molecules perpendicular to the helical axis. d, Atomic model of filament fold, shown for single ANXA11 and TDP-43 molecules aligned with the helical axis. a, b and d, The TDP-43 glycine-rich (G284–G310, magenta), hydrophobic (M311–S342, white) and Q/N-rich (Q343–Q345, green) regions are highlighted. ANXA11 is shown in orange. a and c, The layers of the ANXA11 and TDP-43 chains are indicated with arrows.
