Fig. 3: The ANXA11 and TDP-43 interface in heteromeric amyloid filaments from FTLD-TDP type C.
From: Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C
a,b, Overlay of the cryo-EM reconstruction (a) and hydrophobicity surface plot (b; most hydrophobic in yellow, and least hydrophobic in teal) with the atomic model of the filaments, focused on the interface between ANXA11 and TDP-43 and shown for single ANXA11 and TDP-43 chains perpendicular to the helical axis. The cryo-EM density for TDP-43 is in grey and ANXA11 is in yellow. Buried ordered solvent is indicated with a red dot. c, Atomic model of the interface between ANXA11 and TDP-43, shown for three molecular layers perpendicular to the helical axis.
