Extended Data Fig. 1: Immunohistochemical and immuno-EM analyses of assembled TDP-43 in FTLD-TDP Type C. | Nature

Extended Data Fig. 1: Immunohistochemical and immuno-EM analyses of assembled TDP-43 in FTLD-TDP Type C.

From: Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C

Extended Data Fig. 1

a, Immunohistochemical analysis of prefrontal cortex sections from an individual with FTLD-TDP Type C (individual 1) using an antibody against pS409/410 TDP-43 (brown). Sections were counterstained with haematoxylin (blue). Scale bar, 50 µm. b, Immuno-EM analysis of filament extracts from the prefrontal cortex of an individual with FTLD-TDP Type C (individual 1) using an antibody against pS409/410 TDP-43 and a 10 nm gold-conjugated secondary antibody (black dots). Scale bars, 100 nm. a,b, Similar results were obtained for individuals 2–4.

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