Extended Data Fig. 2: Cryo-EM of additional filament types from individuals with FTLD-TDP Type C.

Representative cryo-EM images of tau paired helical filaments (yellow arrows), Aβ filaments (green arrows) and TMEM106B filaments (cyan arrows) in the filament extracts from the prefrontal and temporal cortex of four individuals with FTLD-TDP Type C. Tau paired helical filaments were identified by their width of ~20 nm and helical crossover distance of ~80 nm; Aβ filaments were identified by their width of ~8 nm and helical crossover distance of ~30 nm; and TMEM106B filaments were identified by their widths of ~12 nm (single protofilament) and ~26 nm (double protofilament), helical crossover distances of ~200 nm and smooth surfaces. Scale bar, 100 nm.