Extended Data Fig. 4: Comparison of filament folds in ALS and FTLD-TDP Type A–C.
From: Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C
a, Schematic of the secondary structure elements of the homotypic TDP-43 filament folds of ALS and FTLD-TDP Type A and B, and the heterotypic TDP-43 and ANXA11 fold of FTLD-TDP Type C. Side chains for R293 are shown. Alternative local conformations (Alt.) of the FTLD-TDP Type A and C folds are transparent. b and c, Amino acid sequence alignment of the secondary structure elements of TDP-43 (b) and ANXA11 (c) in the filament folds. Arrows indicate β-strands. a–c, The TDP-43 glycine-rich (G282–G310, magenta), hydrophobic (M311–S342, white) and Q/N-rich (Q343–Q360, green) regions are highlighted. ANXA11 is shown in orange. R293 is indicated with a blue dot.
