Extended Data Fig. 5: Double-labelling immuno-EM of ANXA11 and TDP-43 in FTLD-TDP Type C filaments.
From: Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C
Double labelling immuno-EM analysis of filament extracts from the prefrontal cortex of an individual with FTLD-TDP Type C (individual 2) using antibodies against pS409/410 TDP-43 and N-terminal ANXA11 (residues 1–180) using 10 nm and 6 nm gold-conjugated secondary antibodies (black), respectively. The filaments label for both ANXA11 and TDP-43. Scale bars, 500 nm. Similar results were obtained for another two individuals with FTLD-TDP Type C.
