Fig. 1: DR extends lifespan in DO mice.
From: Dietary restriction impacts health and lifespan of genetically diverse mice
a, The study design: 960 female DO mice were randomized to one of five diet intervention groups: ad libitum (AL); one day (1D) or two consecutive days (2D) per week fasting; or CR at 20% (20%) or 40% (40%) of estimated adult food intake. b, Kaplan–Meier survival curves by diet group. The dashed lines indicate the median lifespan. Censoring events are indicated by an ‘X’. c, Kaplan–Meier estimates of median (50% mortality) and maximum (90% mortality) lifespan by diet group, showing the percentage change relative to AL and the 95% confidence intervals (computed using R/survfit). n = 937 mice. d, Mortality doubling times estimated from a Gompertz log-linear hazard model, showing the percentage change relative to AL and the 95% confidence intervals (computed using R/flexsurvreg). n = 937 mice. e, Individual mouse lifespans (points) within diet groups. n = 188 (AL), n = 188 (1D), n = 190 (2D), n = 189 (20%) and n = 182 (40%). The box plots show the median lifespan (centre line), quartiles (box limits) and range (whiskers).
