Extended Data Fig. 5: Body composition traits are associated with lifespan.
From: Dietary restriction impacts health and lifespan of genetically diverse mice
a, Total tissue mass (TTM, g) is decomposed into lean tissue mass (LTM, g), fat tissue mass (FTM, g) and adiposity (100% \(\times \) FTM/TTM) for individual mice by diet group (colour) and age (10, 22, 34 months). Sample sizes:10 months n = 895, 22 months n = 689, 34 months n = 241 mice. Boxplots show median, quartiles, and range of data. b, Lifespan by adiposity at 10 months with regression line, 95% confidence band, and diet-specific correlations (padj = 3.56e-5, Diet x Trait:p = 0.00230, r = 0.151). c, Lifespan by adiposity at 22 months (%) with regression line, 95% confidence band, and diet-specific correlations (padj = 4.83e-11, Diet x Trait:p = 0.149, r = 0.202). d, Lifespan by LTM at 10 months (g) with regression line and diet-specific correlations (padj = 4.13e-5, Diet x Trait:padj = 0.0302, r = −0.153). e, Lifespan by FTM at 10 months (g) with regression line, 95% confidence band, and diet-specific correlations (padj = 0.0264, Diet x Trait:padj = 0.00670, r = 0.0920). See Online Methods: Trait Association with Lifespan (panels b-e) for statistical test details.
