Extended Data Fig. 6: Health and metabolic traits.
From: Dietary restriction impacts health and lifespan of genetically diverse mice
a, Kyphosis (scored as 0, 0.5, 1) by age (mean ± 2 s.e.; 5 months n = 770, 10 months n = 909, 16 months n = 834, 22 months n = 704, 28 months n = 489, 34 months n = 260 mice) and by PLL as loess smooth with 95% confidence band (PLL:p < 2.2e-16, Diet:p < 0.00913, Diet x PLL:p = 0.00115). b, Gait disorders (scored as 0, 0.5, 1) by age (mean ± 2 s.e.; sample sizes as in panel a) and by PLL as loess smooth with 95% confidence band (PLL:p < 2.2e-16, Diet:p < 0.192, Diet x PLL:p = 7.78e-4). c, Tumour incidence (scored 0, 0.5, 1) by age (mean ± 2 s.e.; sample sizes as in panel a) and stratified by median 6-month body weight. d, Distended abdomen incidence (scored 0, 0.5, 1) by age (mean ± 2 s.e.; sample sizes as in panel a) and stratified by median 6-month body weight. See Online Methods: Longitudinal Trait Analysis (panels a-d) for statistical test details.
