Extended Data Fig. 10: Genetic mapping of lifespan and RDW.
From: Dietary restriction impacts health and lifespan of genetically diverse mice
a, Genome-wide QTL mapping of lifespan. Horizontal lines indicate genome-wide adjusted significance thresholds for suggestive (blue) and significant (red, adjusted p < 0.05) QTL. b, Genome-wide QTL mapping of RDW as in a. All panels: x-axis is genomic location (chromosome and position), y-axis is LOD score. c, Kaplan-Meier curves within each diet group compare survival of mice stratified by the presence of a CAST allele at the QTL. Statistical significance (p) based on within-diet log rank test comparison of mice with none versus at least one CAST allele at the chromosome 18 QTL peak. d, e, Association mapping of single nucleotide variants (SNVs) for (d) lifespan and (e) RDW across the QTL support interval for RDW (21–23 Mb). Chromosomal position is shown on the x-axis, SNV LOD score on the y-axis. SNVs with LOD score with 1.5 units of the top scoring SNV are highlighted (purple). Annotated genes and gene models are shown in their approximate positions below.
