Extended Data Fig. 1: Food consumption on DR.
From: Dietary restriction impacts health and lifespan of genetically diverse mice
a, Food consumption was measured for four pens (~ 32 mice) per diet group across three non-consecutive weeks. Daily (3 pm to 3 pm) data shown as average consumption (g/mouse/day) per pen and week of assessment (mean ± 2 s.e.; n = 20 pens). Note that food was refreshed weekly on Wednesday for AL mice. b, Cumulative food consumption (g/mouse/day) per pen and week (mean ± 2 s.e.; n = 20 pens). c, Cumulative food consumption in each diet group reported as percent change relative to AL. Significance testing of regression coefficients used a 2-sided Wald test. d, Changes in body weight (BW), lean tissue mass (LTM), fat tissue mass (FTM), and adiposity at 45 and 47 weeks of age. For IF mice, measurements were taken before and after fasting. For CR mice, measurements were taken before the Friday triple feeding and again before refeeding on Monday. AL mice were assessed on Friday and Monday. Points represent individual mice. On x-axis: before-fasting body weight (g), lean mass (g), fat mass (g), and adiposity (100% x fat mass/total mass). On y axis: difference between before and after, same units.
