Extended Data Fig. 2: Metabolic consequences of DR.
From: Dietary restriction impacts health and lifespan of genetically diverse mice
a, Food consumption from one week of metabolic cage data at ~5, 16, and 28 months of age summarized in 4-hour intervals (mean ± 2 s.e.). x-axis labels represent the start of 4-hour intervals in military time. b, Respiratory quotient summarized in 4-hour intervals (mean ± 2 s.e.). c, Energy expenditure (kcal per 4 h, adjusted for body weight) summarized in 4-hour intervals (mean ± 2 s.e.). d, Distance on running wheel (metres per 4 h) summarized in 4-hour intervals (mean ± 2 s.e.). e, Change in respiratory quotient (RQ) (5th to 95th percentile range across one week) showing individuals (points) and averages by diet group and age (mean ± 2 s.e.). f, Energy expenditure showing individuals (points) and averages by diet group and age (mean ± 2 s.e.). g, Cumulative wheel running (kilometres per day) showing individuals (points) and averages by diet group and age (mean ± 2 s.e.). For all panels a-g sample sizes are: 5 months n = 889, 16 months n = 760, 28 months n = 528.
