Extended Data Fig. 17: Summary of findings.
From: Calcium-permeable AMPA receptors govern PV neuron feature selectivity
The abundant CP-AMPARs in PV interneurons were removed by ① targeted expression of GluA2, which ② replaces them with CI-AMPARs. This causes several electrophysiological changes (ⓐ-ⓒ) and ③ increases orientation selectivity in the visual cortex or spatial selectivity in the hippocampus. In excitatory forebrain neurons, which primarily have CI-AMPARs, ④ knocking out GluA2 makes all AMPARs ⑤ calcium permeable. This leads to ⑥ lower orientation selectivity. These results collectively demonstrate a strong role of CP-AMPARs in deciding the feature selectivity of a neuron. Computational modeling reveals that of the three cardinal electrophysiological changes we detect with CP-AMPAR removal (green traces), ⓐ increased intrinsic excitability is likely to decrease selectivity (opposite to our findings), whereas ⓑ decreased inward rectification and ⓒ increased anti-Hebbian LTD are likely to increase feature selectivity (consistent with our findings), providing a potential mechanism of the increased orientation selectivity and spatial selectivity after CP-AMPAR removal observed.
