Extended Data Fig. 8: Correlation between chromatin loop dynamics and CG methylation level of the loop anchor regions.
From: Temporally distinct 3D multi-omic dynamics in the developing human brain
(a) Distribution of the Pearson’s correlation coefficients between loop strength and CG methylation of loop anchor regions for developmentally differential loops. (b-e) Correlation between loop strength and CG methylation of loop anchor regions across astrocyte differentiation. (b) Normalized loop contact frequencies (cyan) and CG methylation levels of anchor regions (magenta) across meta-cells ranked by developmental pseudotime scores. (c-d) Normalized values of loop interaction frequency (c) and CG methylation of loop anchor regions (d). (e) Quantification of the lag of CG methylation remodeling by the amount of pseudotime shife (in counts of meta-cells) required to maximize the inverse correlation between loop strength and CG methylation levels of loop anchor regions. (f-i) Correlation between loop strength and CG methylation of loop anchor regions across the differentiation of cortical upper layer excitatory neurons.
