Extended Data Fig. 10: Heritability enrichment analysis of neuropsychiatric disorders.
From: Temporally distinct 3D multi-omic dynamics in the developing human brain
(a-b) The enrichment of polygenic heritability for bipolar disorder (a), major depression (b), ADHD (c), ASD (d), Alzheimer’s disease (e), and height (f) in DMRs and loop-connected DMRs. (g) The genomic region overlapping with a putative causal variant for schizophrenia rs500102 is connected to the RORB promoter through a cell-type-specific loop domain. (h-m) Enrichment of polygenic heritability for neuropsychiatric disorders across developmental stages in PFC-Exc-L5-6-PDZRN4 (h), PFC-Exc-L1-3-CUX2 (i), PFC-Exc-L4-5-FOXP2 (j), HPC-Exc-CA1 (k), PFC-Inh-MGE-ERBB4 (l), PFC-Inh-CGE-CHRNA2 (m). (n-o) Meta-analysis of heritability enrichment for neuropsychiatric disorders in excitatory (n) and inhibitory (o) neuron populations.
