Extended Data Fig. 2: Comparison of brain cell type classification using DNA methylation and chromatin confirmation signatures.
From: Temporally distinct 3D multi-omic dynamics in the developing human brain
(a) Methylation dimensionality reduction using UMAP distinguishes, from left to right, cell types, major cell lineages, brain regions, and sample age groups. (b) Chromatin conformation dimensionality reduction using UMAP distinguishes, from left to right, cell types, major cell lineages, brain regions, and sample age groups. (c) Riverplot to show extensive consistency in adult major cell lineage annotation between DNA methylation and chromatin conformation modalities. (d) Dimensionality reduction using UMAP shows resolution difference in cell-type classification using DNA methylation and chromatin conformation modalities in adult inhibitory neurons; CGE-derived (top), MGE-derived (bottom). (e) Showing distinction of RG-1 and RG-2 populations in methylation space (left), chromatin conformation space (middle), and joint dimensionality reduction space (right). (f) Dimensionality reduction of z-scored CG methylation feature matrix for cells from mid-gestational brains (left). Chromatin conformation dimensionality reduction of cells from mid-gestational brains (right).
