Extended Data Fig. 5: Minimal model based on the hypoglycaemic study in LYD pigs quantifying the change in NNC2215 activity depending on glucose concentration.
From: Glucose-sensitive insulin with attenuation of hypoglycaemia
a, Parameters for the minimal model. Data are typical values from a non-linear mixed effects model. Endogenous insulin was confirmed by bioanalysis to have been suppressed by the somatostatin infusion, and hence this contribution was set to 0 in the model. aInterindividual variation: 86%. bInterindividual variation: 38%. Correlation with P2: 44%. b, Model-based SI index for NNC2215 as a function of plasma glucose. The simulation was based on typical values from the pharmacokinetic/pharmacodynamic model. SI was expressed as 0.00673 • Glucose concentration/(50 + Glucose concentration). The SI index for a given glucose concentration was calculated as the SI for that glucose concentration in percent of the SI for a glucose concentration of 5.5 mM.
