Fig. 3: Glucose-dependent hIR-A affinity of NNC2215.
From: Glucose-sensitive insulin with attenuation of hypoglycaemia
a–c, Representative displacement curves of 125I-insulin from hIR-A for NNC2215 (a), human insulin (b) and insulin degludec (c) in the presence of 0 to 20 mM d-glucose. Data are mean ± s.d. n = 3 technical replicates. For some datapoints, the s.d. error bars are shorter than the size of the symbols. d, hIR-A affinity of NNC2215 and insulin degludec relative to human insulin over increasing glucose concentrations. Data are mean ± s.d. n = 3 independent replicates. For some datapoints, the s.d. error bars are shorter than the size of the symbols. e, Representative curves of NNC2215 and insulin degludec dose-dependent conversion of 3H-d-glucose into lipid in isolated rat adipocytes at low (3 mM) and high (20 mM) l-glucose concentrations. Data are mean. n = 2 technical replicates. CPM, counts per minute.
