Table 1 Glucose sensitivity of NNC2215 activity with respect to hIR-A binding and downstream metabolic response
From: Glucose-sensitive insulin with attenuation of hypoglycaemia
hIR-A affinity relative to human insulina (%) | ||||||
|---|---|---|---|---|---|---|
d-Glucose (mM) | l-Glucose (mM) | |||||
0 | 3 | 5 | 10 | 20 | 20 | |
NNC2215 | 0.75 ± 0.1 | 2.9 ± 0.4 | 4.3 ± 0.4 | 6.5 ± 1.0 | 9.2 ± 0.9 | 5.7 ± 0.8 |
Insulin degludec | 0.36 ± 0.01 | 0.35 ± 0.03 | 0.36 ± 0.03 | 0.37 ± 0.03 | 0.37 ± 0.04 | 0.49 ± 0.08 |
hIR-A affinity relative to human insulin (fold change between glucose concentrations) | Lipogenesis (fold change between glucose concentrations) | |||||
d-Glucose (mM) | l-Glucose (mM) | |||||
20 vs 3 | 20 vs 0 | 20 vs 0 | 20 vs 3 | |||
NNC2215 | 3.2 ± 0.3 | 12.5 ± 1.7 | 7.6 ± 0.8 | 2.2 ± 0.5 | ||
Insulin degludec | 1.1 ± 0.2 | 1.0 ± 0.1 | 1.4 ± 0.2 | 1.1 ± 0.2 | ||
