Extended Data Table 1 Non-compartmental and compartmental pharmacokinetic analysis

From: Glucose-sensitive insulin with attenuation of hypoglycaemia

  1. a, Non-compartmental analysis estimates of clearance, volume of distribution and elimination half-life of NNC2215, insulin degludec and human insulin after intravenous administration in rats and LYD pigs. Data are arithmetic mean ± SD for clearance and volume of distribution and harmonic mean ± pseudo SD for elimination half-life. Rat studies n = 8 animals for NNC2215, n = 5 animals for insulin degludec and n = 3 animals for human insulin. LYD pig studies n = 3 animals for NNC2215 and n = 8 animals for insulin degludec and human insulin. b, Pharmacokinetic parameters for the 2-compartment model of NNC2215 in LYD pigs. Data are typical values from non-linear mixed effects model. aInterindividual variation: 34%.
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