Extended Data Fig. 3: Assessment of conservation and codon usage across genes.
From: Quantifying constraint in the human mitochondrial genome
Median phyloP base conservation scores for each protein (a) or RNA (b) gene, derived from 100 vertebrate genomes. Higher phyloP values represent increased conservation. (c) The count of codons within the protein-coding sequence corresponding to each tRNA. Pearson correlation coefficient (R) and its p-value (p) computed using a two-sided test is shown in (a-c). OEUF stands for observed:expected ratio confidence interval upper bound fraction, and OEUF values for (a-c) are provided in Supplementary Dataset 1.
