Extended Data Fig. 7: Assessment of cardiac and blood leukocytes and plasma corticosterone.

a, UMAP of heart leukocytes. n = 5 pooled mice per group. b, Subclustering of cardiac macrophages and cluster frequencies in MI and MI + SF mice. n = 5 pooled mice per group. c, UMAP depicting resident and recruited heart macrophages and defining genes. n = 5 pooled mice per group. d, DEGs in recruited macrophages. n = 5 pooled mice per group. e, UMAP of blood leukocytes and monocytes along with monocyte DEGs and top pathways of genes enriched in MI + SF versus MI mice. n = 5 pooled mice per group. f, Plasma corticosterone levels. Each data point represents an individual mouse. g, Leukocyte enumeration in the infarct. n = 9 MI + SF; n = 8 MI + SF + ADRβ2 blocker. h, Analysis of ejection fraction (EF) and infarct leukocyte abundance in WT mice transplanted with WT BM or Adrb2^−/− BM and exposed to MI and SF. Analysis was performed 3 days after infarct. n = 5 WT^bmWT; n = 4 WT^{bmAdrb2−/−}. Data are mean ± s.e.m. Statistical analysis was done using two-tailed unpaired t-tests. Experiments were conducted in female mice. *p < 0.05, **p < 0.01, ***p < 0.001.