Extended Data Fig. 9: Model of leptin regulation of feeding and energy balance in ARC microcircuits.
From: Leptin-activated hypothalamic BNC2 neurons acutely suppress food intake
Leptin-activated BNC2 neurons acutely promote satiety by suppressing AGRP/NPY neurons, which rapidly stimulates hunger. POMC neurons restrict weight gain by modulating energy balance over the long term with minimal short-term effects on food intake.
