Fig. 7: Offline activity of mFC neurons is internally organized by the task structure. | Nature

Fig. 7: Offline activity of mFC neurons is internally organized by the task structure.

From: A cellular basis for mapping behavioural structure

Fig. 7

a, Schematic showing potential neuronal state spaces. Neuronal state space relationships are best described by circular distance for a ring and forward distance for a delay line. Reproduced/adapted with permission from Gil Costa. b, Schematic showing the linear regression model relating pairwise circular distance and forward distance with coactivity during sleep while regressing out each other, as well as pairwise goal-progress-tuning distance and spatial map similarity. c, Regression coefficient values for circular distance against sleep cross-correlation were more negative for pairs sharing the same anchor (within) compared with pairs across anchors (between). One-sided unpaired t-test (Welch’s t-test) for all sleep: n = 430 pairs (within), 13,932 pairs (between), t = −1.80, P = 0.036, d.f. = 14,360. d, A plot of sleep cross-correlations (between pairs sharing the same anchor) against forward and circular distance (bottom and top x axes, respectively). Schematics at the top and bottom show example pairs that would fall into each category and their circular and forward distances. The v-shaped relationship between forward distance and cross-correlation indicates a circular state space. Inset, kernel density estimate plots showing distribution of cross-correlation values across bins. Reproduced/adapted with permission from Gil Costa. e, Bar graph (top) and scatter plot (bottom) of correlation coefficients between pairwise forward distance and pairwise sleep cross-correlations are positive for pairs of neurons with 180–360° forward distance and negative for pairs with a forward distance of 0–180°. Two-sided t-tests relative to 0, 0–180°: n = 59 sleep sessions, t-statistic = −5.16, P = 1.07 × 10−4, d.f. = 58; 180–360°: n = 59 sleep sessions, t-statistic = 4.16, P = 1.08 × 10−4, d.f. = 58. Two-sided paired t-test: n = 59 sleep sessions, t-statistic = −5.55, P = 7.35 × 10−7, d.f. = 58. Data are mean ± s.e.m. In c, this error is analytically derived for each regression; thus there are no individual points to report in this panel.

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