Extended Data Fig. 2: Biological circuit maps.
From: Spatially restricted immune and microbiota-driven adaptation of the gut
a, Top 10 Gene Ontology (GO) terms (left, Biological Processes; right, Molecular Functions) enriched for marker genes of each tissue (top 100 marker genes ranked by Wilcoxon test p-value; all have adjusted p-value < 0.05; enriched GOs are significant with adjusted p-value < 0.05 by Fisher’s exact test). b, Spatial heatmap showing the expression (Z-score) of the upregulated SLC transporter genes in Fig. 1c. The heatmap columns are arranged based on the coordinates of the unrolled axes aligned across three replicates. The network to the right connects the SLC transporters with their known ligands. c, Dot plot showing the expression of regionally variable curated GPCRs (upregulated in at least one section of SI or colon). d, Dot plots showing the expression of disease risk-associated nuclear receptors. e, Dot plot showing the expression of all fine mapped IBD risk genes irrespective of regional enrichment. f, Dot plot showing the expression of regionally variable (upregulated in at least one section of SI or colon) monogenic IBD genes with average expression >0.6 (normalized and log transformed). D, duodenum; J1, jejunum 1; J2, jejunum 2; I, ileum; C, colon; C1, proximal colon; C2, middle colon; C3, distal colon.
