Extended Data Fig. 3: Biological circuit maps and distal region shared gene expression.
From: Spatially restricted immune and microbiota-driven adaptation of the gut
a-b, Dot plots showing the expression of disease risk-associated genes (a) and transcription factors (b) along the intestine. Only regionally variable genes and with average expression >0.6 (normalized and log transformed) in at least one segment of SI or colon were shown. c, Expression of regionally variable transcription factors (expressed in >30% in any one region but <5% in any other regions) along the unrolled axis (n = 3 biological replicates). Heatmaps on the left summarize the average scaled expression of genes along the serosa-to-epithelium axis (only spots with scaled expression >0.5 considered). d, Expression of solute carrier family transporters along the intestinal length. e, Scaled expression of Onecut2, Hoxb13, Tmprss2 along the intestine of SPF mice (n = 3). Lines depict the locally weighted scatterplot smoothing curves. D, duodenum; J1, jejunum 1; J2, jejunum 2; I, ileum; C, colon; C1, proximal colon; C2, middle colon; C3, distal colon; CeD, coeliac disease; DD, diverticular disease; CD, Crohn’s disease; UC, ulcerative colitis; IBD, irritable bowel disease; CID, chronic inflammatory diseases; Ped. AD, pediatric autoimmune diseases.
