Fig. 3: Polygenic background in parents of patients with neurodevelopmental conditions.
From: Examining the role of common variants in rare neurodevelopmental conditions
a, pTDT in undiagnosed probands with unaffected parents. Plotted is the mean pTDT deviation (difference between the child’s polygenic score and the mean parental score, in units of the s.d. of the latter) in trios from GEL and DDD (N = 2,866, or N = 1,567 for testing PGSNDC,DDD). We tested whether this is significantly different from 0 using two-sided one-sample t-tests. b, Mean polygenic scores for undiagnosed probands or their unaffected parents in the trios used in the pTDT analysis, standardized using the weighted MCS controls whose mean is indicated by the dotted line. See Supplementary Tables 9 and 7 for results of pTDT and two-sided t-tests, respectively. Subgroups that have a significantly different average polygenic score from controls are indicated by an asterisk (*P < 0.05) or double asterisk (**P < 0.01 after Bonferroni correction for five polygenic scores). Error bars in both plots show 95% confidence intervals.
