Fig. 1: Chirality in protein–protein interactions.
From: Stereochemistry in the disorder–order continuum of protein interactions
a,b, l- and d-amino acids (a) and l- and d-proteins are mirror images of each other, illustrated in b by ubiquitin (Protein Data Bank (PDB): 4GSW). c, The five protein pairs constituting our model system covering a continuum of disordered (ProTα:H1)22,24 to ordered (MCL1:PUMA)25 protein complexes, and three intermediate interactions of RST with ANAC046, DREB2A28 and ANAC013. d, l-protein pairs will interact, but the features that might allow l-proteins and d-proteins to interact are unclear.
