Extended Data Fig. 6: Effects of FetuA on HSPCs.
From: Fetal hepatocytes protect the HSPC genome via fetuin-A
a, Scatter-plots showing the consistency of ATAC-seq replicates for each group (n = 3). b, Fragment size distribution of ATAC-seq data (n = 3). c, ATAC-seq signals of Blm, Fanci and Smarcc1 in Integrative Genomics Viewer are shown; the red boxes indicate the peaks where the bZIP motifs are located (n = 3). d, Heatmaps showing the Cut & Tag peak signal intensities (n = 2). e, Cut & Tag sequencing signals of Jun, JunB and Fosl1 on the Blm gene from the Integrative Genomics Viewer are shown (n = 2). Cut & Tag for Jun binding to the Blm promoter. f, Western-blots analysis of the BLM protein in LSK cells from E12.5 FL and E16.5 FL (n = 2). g, h, Western-blots and relative signal intensity of the BLM protein in Lin– cells cultured with or without FetuA at different time points (n = 3; mean ± s.d.). The n represents independent experiments. Statistical tests: unpaired two-sided Student’s t-test (h).
