Extended Data Fig. 6: Structure of the sperm-specific RS2-RS3 bridge.
From: Structural diversity of axonemes across mammalian motile cilia
(a) The bridge between RS2 and RS3 is formed by the interaction of RGS22, a conserved ciliary protein, with EFCAB5, a sperm-specific protein. The sperm-specific RS3 proteins LRRD1 and STKLD1 interact with EFCAB5 to further support the bridge, along with an unassigned globular density (asterisk). (b) Superposition of RGS22 from RS1 and RS2 showing a large conformational change, potentially induced by binding EFCAB5. (c) Cryo-EM density and corresponding atomic models are shown for the interaction site between RGS22 and EFCAB5.
