Extended Data Fig. 8: Structures and conformations of radial spoke-anchored adenylate kinases (AKs).
From: Structural diversity of axonemes across mammalian motile cilia
(a) RS1 and RS2 each have one copy of AK8, while RS3 has two copies of AK7 and one copy of AK9. (b) Models of axonemal AKs with catalytic domains labelled. (c) Catalytic domains of axonemal AKs are observed in either open (PDB 4AKE)23 or closed (PDB 1AKE)22 conformations. Densities consistent with small molecules in the putative nucleotide-binding pockets are shown in pink. These densities were colored by aligning PDB 1AKE to the relevant adenylate kinase domain and coloring density within 3 Å of the ligand atoms.
