Extended Data Fig. 3: OrthoSNIPR activation and tuning.
From: Engineered receptors for soluble cellular communication and disease sensing
a, Individual activation analysis of the 5 × 5 receptor ligand screen shown in Fig. 3c. n = 3 technical replicates. Error bars represent SEM. b, Activation of Jurkat T cells expressing orthoSNIPR and a corresponding variant bearing the hmSNIPR hinge cysteine substitution using orthoLigand C1-active at 200 nM (n = 3 technical replicates; error bars represent SEM). Statistics were computed using Welch’s unpaired t-test.
