Extended Data Fig. 7: PDACs alter diversity and composition of gut microbiota.
From: IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer
a, Pancreatic KLRG1+ ILC2 frequency in sham-treated and PDAC mice. b, Experimental schema and faecal microbiome analyses in PDAC mice by alpha diversity (Shannon index, left) and principal coordinate analysis (right). c, Experimental schema, serum IL-33, and gut KLRG1+ ILC2s in rIL-33-treated PDAC mice with and without antibiotic (Abx) treatment. d, Gut KLRG1+ ILC2s in germ-free PDAC mice with and without faecal microbial transplantation (FMT) from WT mice. Data collected 3 (a, b) and 4 (c, d) weeks after tumour implantation, pooled from ≥2 independent experiments with n ≥ 3 mice per group with consistent results. n = individual measurements from individual mice analysed separately. Horizontal bars = median. P values by two-tailed Mann-Whitney test (a, c, d) and Welch’s t-test (b).
