Fig. 2: Fitness values provide structural, functional and evolutionary insights into rubisco. | Nature

Fig. 2: Fitness values provide structural, functional and evolutionary insights into rubisco.

From: A map of the rubisco biochemical landscape

Fig. 2

a, Structure of R. rubrum rubisco homodimer (Protein Data Bank (PDB) 9RUB) coloured by the average fitness value of a substitution at every site. Asterisks denote active sites. b, Variant effects for amino acids in different parts of the homodimer complex. c, Close-up view of the active site and the mobile Loop 6 region. Radar plots show the fitness effects of all mutations at a given position. d, Comparison of average fitness at each position against phylogenetic conservation among all rubiscos. Positions coloured as in b. Positions 215 and 257 form a tertiary interaction (Extended Data Fig. 8c), position 186 is highly conserved with no known function.

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