Extended Data Fig. 4: Systems homologous to the Lysobacter gasdermin system.
From: CARD domains mediate anti-phage defence in bacterial gasdermin systems
a. Efficiency of plating of phages infecting E. coli cells that express the Lysobacter or Pedobacter defense systems. Negative control is a strain in which GFP is expressed instead of the gasdermin system. Data represent plaque-forming units (PFU) per milliliter. Average of three independent biological replicates, with individual data points overlaid. b. Representative instances of homologous systems in their genomic neighborhood. Genes known to be involved in anti-phage defense are shown in yellow (RM, restriction-modification; Pycsar, pyrimidine cyclase system for anti-phage resistance; AIPR, abortive infection phage resistance; REase, restriction endonuclease). c. A plot of DALI Z-scores of protein structures similar to the Azospirillum CARD domain structure.
