Fig. 1: Analyses of DepMap data to identify dependencies associated with 9p21.3 deletion.
From: SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO
a, Illustration of chromosome 9 cytoband 9p21.3, which is biallelically deleted (9p21.3−/−) in approximately 13–15% of human cancers. b, Histogram of 9p21.3 relative copy number across DepMap cell lines (n = 1,750). Threshold of less than 0.4 (dashed line) indicates cell lines characterized as 9p21.3−/−. c, q-values from left-tailed Student’s t-test between 9p21.3−/− (less than 0.4 threshold, n = 63 cell lines) or at least one intact copy of 9p21.3 (9p21.3+, n = 1,037 cell lines) plotted against the mean difference in gene dependency in DepMap. d, PELO dependency plotted against 9p21.3 relative copy number (n = 1,100 cell lines), with MSI-H cell lines (MSIsensor2 MSIScore > 20, n = 73) highlighted. e, Univariate associations of DepMap omics data with PELO dependency score in 9p21.3+ cell lines (n = 1,037). f, PELO dependency score for cell lines (n = 1,100) grouped by OncoTree lineage. Ovary, ovary and/or fallopian tube; bladder: bladder and/or urinary tract; soft, soft tissue; stomach, oesophagus and/or stomach; head/neck, head and neck; PNS, peripheral nervous system; biliary, biliary tract; ampulla, ampulla of Vater. Relative copy number, gene dependency and omics data are from DepMap 23Q4 or 24Q2 release.
