Extended Data Fig. 1: Analyses of functional genomic datasets identify PELO as preferential dependency.
From: SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO
(a) Upper figure: histogram of 9p21.3 relative copy number across cell lines. Dashed vertical lines represent 9p21.3 relative copy number thresholds between 0.2 and 0.6 tested for calling 9p21.3−/−. Lower figures: q-value from left-tailed Student’s t-test plotted against the mean difference of gene dependency scores between 9p21.3−/− or 9p21.3+cell lines for each indicated threshold. (b) q-value from two-tailed Student’s t-test plotted against the mean difference of dependency scores between 9p21.3+/MSI-H (n = 71) and 9p21.3+/MSS cell lines (n = 966).
